Wetzel Chemistry Consulting, LLC
Albany, OH,
2005-present, Principal
Lundbeck Research USA
Paramus, NJ.
2003-2005, Director, Chemistry Support Services
—– Led project teams for MCH1 antagonist discovery and Chemistry Technology Platform development.
—– Co-led the selection of an automated storage / retrieval strategy for the Lundbeck screening collection worldwide.
Synaptic Pharmaceutical Corporation
Paramus, NJ.
1990-2003, positions of increasing responsibility, culminating in Director, Department of Chemistry
—– Managed 40 FTEs, including Medicinal, Computational, Analytical and Bioanalytical Chemists.
—– Managed the outsourcing of Chemistry, Manufacturing and Controls (CMC) efforts for preclinical and clinical development of a novel anti-depressant, including chemical process development, GMP-compliant synthesis, GLP-compliant analysis and bioanalysis, and formulation. Contributed CMC section to IND filing and annual update.
—– Designed and synthesized alpha-1a adrenoceptor antagonists for treatment of benign prostatic hyperplasia.
—– Discovered the first subtype-selective alpha-1a antagonist, SNAP 5089
—– Discovered highly selective alpha-1d adrenoceptor antagonists exemplified by SNAP 8493.
—– Designed and implemented a novel strategy for the efficient characterization, purification and formatting of combinatorial libraries culminating in neat solid archive samples.
—– Developed a novel LCMS-guided HPLC purification strategy for library purification.
—– Conducted numerous HPLC separations, including enantioselective separations and high throughput library purifications, on milligram and gram scales.
—– Procured and maintained NMR, LCMS, HPLC and other instruments.
Suntory Institute for Bioorganic Research
Osaka, Japan
1988-1990, Postdoctoral Fellow
—– Explored the chemical relationship between the brown planthopper (Nilaparvata lugens) and its intracellular yeast-like symbiote through deuterium labeling and GCMS techniques.

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