2010/2011: Past Meetings

The following is a summary of previously held meetings in 2011/2010 listed in reverse chronological order.
Thursday, April 14, 2011
Luncheon Meeting
Topic: “Using Fiber Reinforced Polymeric (FRP) Materials for Concrete Repair – A Repair Project at the UN Naval Weapons Center Earle”
Speaker: Howard Kliger

Abstract: The use of FRP materials for repair and strengthening of concrete structures will be described. Concepts of repair as well as a description of resins, fibers and material forms will be given. The FRP application process is explained. Finally, a local project, strengthening of the Naval pier at Sandy Hook NJ will be described in detail.

Bio: Howard Kliger is an engineering and marketing consultant to the composites industry specializing in industrial and sports related products. He has also been very active in efforts to bring fiber sheet wrapping materials to the infrastructure market. He has authored numerous papers and has been an active member of SAMPE since 1975. Also, as an Adjunct Professor, he teaches a Mechanics of Solids structures course and a graduate composites course at Rutgers University. Some of the more interesting projects he has worked on during a 40 year career include design and prototype development of composite torque shafts for Nascar racers, design of an all composite flatbed trailer truck, prototype development and material qualification of composite sport goods such as the Prince Vortex tennis racquet and the Abu Garcia Royal Nickel fishing rod, and strengthening of the concrete pier at the Earle Naval Weapons Center at Sandy Hook NJ.

Please join us for this luncheon meeting at 12:30 pm.
MEETING DATE: Thursday, April 14, 2011

PLACE: Snuffy’s Restaurant, Park & Mountain Ave (Route 22 East), Scotch Plains, NJ Telephone: 1-908-322-7726

TIME: 12:30 pm Lunch followed by the Presentation

REGISTRATION: $35 ACC&CE Members, $45 Non-members

DIRECTIONS: See below

To RESERVE: Call 1-973-729-6671 or e-mail: accce@chemconsult.org

Tuesday, November 30, 2010
Luncheon Meeting
Topic: “Developing 3D Tissue Models Using Polysaccharide-based Biopolymers for Tissue Engineering and Drug Testing “
Speaker: Cheul H. Cho, Ph.D., Dept of Biomedical Engineering
New Jersey Institute of Technology

Abstract: My research interests involve stem cell bioengineering, tissue engineering, and polymeric biomaterials. The main research goal of our lab is to employ cellular and molecular engineering approaches to engineer cells, matrix, and biomaterials towards the development of functional 3D in vitro models for drug testing and tissue regeneration. Our group is using natural polysaccharide biopolymers (e.g. chitosan, alginate) to fabricate different types of scaffolds (nanofibers, microspheres, hydrogels) using various techniques for their use in cell support and growth factor delivery. In order to promote cell affinity and growth factor binding, the scaffolds are modified using ionic and covalent attachment of bioactive molecules. In vitro degradation assay of the chitosan scaffolds by lysozyme is performed to assess their stability and degradation time. The polysaccharide-based scaffolds are extensively characterized by spectrophotometer, FT-IR, SEM, and mechanical testing to evaluate their physical and mechanical properties. Cells (e.g. heart, nerve) are studied for their morphological and structural changes on the scaffolds. To better understand cell and protein interactions on biomaterial surfaces, micropatterning techniques are employed. Theses studies will provide a greater understanding of cell-cell and cell-biomaterial interaction that regulate tissue remodeling and will be used to improve the design of engineered 3D tissue models for drug screening and tissue repairs.

Biographical Sketch: Dr. Cheul H. Cho, Ph.D., is an Assistant Professor in the Department of Biomedical Engineering at New Jersey Institute of Technology (NJIT). He is also an Adjunct Assistant Professor of Cell Biology and Molecular Medicine at the UMDNJ-New Jersey Medical School. Prior to his joining NJIT in 2007, he has completed 4-year postdoctoral fellowship in Center for Engineering in Medicine at Harvard Medical School in the field of stem cells and liver tissue engineering. He obtained B.S degree in Chemical Engineering from Dong-A University in Busan, South Korea, M.S. degree in Biomedical Engineering from University of Iowa, and Ph.D. degree in Chemical Engineering from Wayne State University. Previously, he worked as a research scientist in Biomedical Research Center at Korea Institute of Science and Technology (KIST), the well-known national research institute in South, Korea. He has served as an invited reviewer of FASEB Journal, Tissue Engineering, and Journal of Biomedical and Materials Research. He has published over 10 scientific articles and a full patent application on embryonic stem cell differentiation techniques into liver lineage. Dr. Cho has recently received the prestigious Coulter Foundation Translational Awards for his promising patent application.
Please join us for this luncheon meeting at 1 pm.
MEETING DATE: Tuesday, November 30, 2010.

PLACE: Snuffy’s Restaurant, Park & Mountain Ave (Route 22 East), Scotch Plains, NJ Telephone: 1-908-322-7726

TIME: 1 pm Lunch followed by the Presentation

REGISTRATION: $35 ACC&CE Members, $45 Non-members

DIRECTIONS: See below

To RESERVE: Call 1-973-729-6671 or e-mail: accce@chemconsult.org

Tuesday, October 26, 2010
Dinner Meeting
82nd Anniversary Annual Membership Meeting at Ben’s Deli, New York
Speaker: Dr. Richard M. Goodman

ANNUAL MEMBERSHIP MEETING DATE: Tuesday, October 26th
1928–2010 82nd Anniversary

PLACE: Ben’s Deli, 209 West 38th St (between 7th and 8th Ave), New York, NY
Telephone: 1-212-398-2367

TIME: 6 pm Networking/Cash Bar, 6:30 pm Dinner/Presentation

REGISTRATION: $35 ACC&CE Members, $45 Non-members

Advanced registration required.

To RESERVE: Call 1-973-729-6671 or e-mail: accce@chemconsult.org

Tuesday, Sept. 28, 2010
Dinner Meeting
Topic: “Modeling and Control of Downstream Pharmaceutical Processes”
Speaker: Dr. Rohit Ramachandran, Rutgers University

Downstream pharmaceutical processing consists of a series of unit operations in which an active pharmaceutical ingredient (API) is converted into a final dosage form (e.g. tablet). Typically this encompasses a series of purification steps (crystallization – filtration -drying) followed by the final dosage form production steps (granulation – drying -milling – blending – compression – coating). The focus of this talk is on granulation which is a particle agglomeration process of converting fine powdery solids into larger free-flowing granules. In batch granulation, it is of interest to develop a systematic strategy for scale-up of high-value added products. Currently scale-up is poorly understood and this can lead to batch failure at the production scale. Thus, there is an immediate economic incentive for a more fundamental model-based understanding of the granulation process which could lead to a more efficient operation, control and scale-up of granulation units. Current granulation models are typically empirical and/or semiempirical in nature. As a result, scale-up and control of granulation processes are often based on heuristics and/or operator experience. Many continuous granulation plants operate well below their design capacity, suffering from high recycle rates and instabilities caused by disturbance amplification effects. A granulation model based on first-principles mechanistic understanding (i.e., based on the physics and chemistry of the process) will be presented in this seminar. Results will elucidate that the mechanistic representations of the granule formation could lead to improved scale-up and control. The predictive nature of such models can also result in reduced labor- and capital-intensive experiments required for model calibration.
Dr. Rohit Ramachandran is currently an Assistant Professor at the Department of Chemical & Biochemical Engineering at Rutgers University . He completed his Bachelors and Masters in Chemical Engineering at the National University of Singapore. He then went on to pursue his doctoral studies at Imperial College London, also in Chemical Engineering. This was followed by a postdoctoral position at the Department of Chemical Engineering at MIT. His research interests include modeling, control and optimization related to pharmaceutical and chemical processes. MEETING DATE: Tuesday, September 28, 2010.

PLACE: Snuffy’s Restaurant, Park & Mountain Ave (Route 22 East), Scotch Plains, NJ Telephone: 1-908-322-7726

TIME: 6:00 pm Cash Bar, 6:30 pm Dinner, 7:30 pm Presentation

REGISTRATION: $35 ACC&CE Members, $45 Non-members

CANCELLATIONS must be made 24 hrs in Advance or Be Invoiced.

DIRECTIONS: See below

To RESERVE: Call 1-973-729-6671 or e-mail: accce@chemconsult.org

Thursday, June 24, 2010
Dinner Meeting
Topic: “What We Can Learn from DSC”
Speaker: Dr. Michael M. Blumenthal, Libra Technical Center LLC

Differential Scanning Calorimetry is a simple technique of thermal analysis. The many uses of DSC include determining melting points, boiling points, phase and glass transitions, purity, and heat capacity. The range of temperatures normally covered are from about -80 to +725°C. Many industries use DSC information for research, testing, and quality and process control. A variety of applications will be presented, and discussion welcomed.

Dr. Mike Blumenthal recently received his 50th year pin from the ACS which he joined at age 17. His industrial research background was in physical and analytical chemistry, and process engineering development of lipids and specialty chemicals, food, and packaging. He has operated the Libra Labs affiliated companies for 30 years including an international consulting practice, and was one of the first in the world to design and commercialize scientific and management software suites for personal computers. He is unflagging in his thirst for new knowledge and projects. Mike’s latest interest is in three-dimensional printing which largely depends on the thermal, sensory, and rheological properties of specialty materials, process equipment, and computer control.
Please join us for a Gourmet Hot/Cold Buffet Dinner. Advanced reservations recommended.
MEETING DATE: Thursday, June 24, 2010.

PLACE: Snuffy’s Restaurant, Park & Mountain Ave (Route 22 East), Scotch Plains, NJ Telephone: 1-908-322-7726

TIME: 6:00 pm Cash Bar, 6:30 pm Buffet Dinner, 7:30 pm Presentation

REGISTRATION: $35 ACC&CE Members, $45 Non-members

CANCELLATIONS must be made 24 hrs in Advance or Be Invoiced.

DIRECTIONS: See below

To RESERVE: Call 1-973-729-6671 or e-mail: accce@chemconsult.org

Thursday, May 27, 2010
Dinner Meeting
Topic: “The Importance of Science and Engineering in Agriculture”
Speaker: Richard L. Schauer, Ph.D., Schauer Associates

Each year American farmers produce enough food to feed 300 million people, enough feedstocks to produce millions of gallons of ethanol and biodiesel fuels and more than 100 billion dollars worth of additional ag products to export. Over the past 200 years, many scientists have worked to improve seeds, manufacture fertilizers, develop pesticides and reduce environmental pollution. Engineers have built powerful tractors, tillage implements, planters and harvesting equipment. The end result is that less than 2 percent of the American population is involved in production agriculture thus allowing the other 98 percent of the population to enjoy an abundant lifestyle. But, the next challenge is to produce enough food to also feed the additional 100 million people that will be added to our population by 2050 while reducing carbon emissions and environmental impacts. Many new scientists and engineers will be needed to develop the new technologies and equipment to meet this challenge

Richard Schauer was reared on a farm in Central New Jersey, earned a BS and a MS in Agronomy from Rutgers University and earned a Ph.D. in Agronomy from West Virginia University. He spent 14 years with Diamond Shamrock Corporation traveling around the World developing and registering new pesticides. He also spent 14 years at ICI Americas Inc. as a chemical regulatory manager. Since 1992, he has been a chemical regulatory consultant. He keeps up with agricultural practices of his farmer neighbors in rural Delaware as well as growing Christmas trees on his own farm.

Thursday, April 29, 2010
Dinner Meeting
Topic: “Economic Opportunities in NJ’s Changing Energy Infrastructure”
Speaker: Stefano Crema, Ph.D., Cooling America thru Local Leadership (CALL)

Availability, cost and quality of energy are going to strongly influence the future development of New Jersey communities. Today, for the most part, these variables are outside of local control. The Community Clean Energy Aggregation (CCEA) program allows communities to cooperate to a) control energy (electricity and natural gas) procurement costs, b) reduce overall demand through conservation and c) grow an alternative energy infrastructure based on renewable and distributed generation assets. This approach will control the variability of energy prices, improve the value of local real estate, reduce the effect of future carbon taxes on the local economy and create a substantial number of “green jobs.”

Stefano Crema received his PhD in Chemistry from Monash University in Melbourne, Australia, and his Bachelor/Master’s degree in Chemistry from Padua University, Italy. During his more than 25 year career in the chemical industry, Dr. Crema has worked on various projects connected with the energy industry and, lately, was in charge of developing emission reducing additives for automotive applications. He has recently retired from BASF Corporation where he held the position of Research and Development manager in Wyandotte, MI and Director of Marketing in the North American Headquarters in Florham Park, NJ. Dr. Crema has been working since his retirement in 2006 on Global Warming and Renewable Energy issues. In 2008, he started with some colleagues, Cooling America thru Local Leadership (CALL), a non-profit dedicated to the improvement of the energy infrastructure in New Jersey.
Please join us for dinner. Advanced reservations recommended.

Thursday, April 1, 2010
Dinner Meeting
Topic: “The World’s First 1,000 MW Solar-Hydrogen Demonstration Power Plant”
Speaker: Béla Lipták, PE, Lipták Associates

ABSTRACT: Three topics will be covered:
1) The design of a 1,000 MW solar power plant generating liquid hydrogen to be stored and transported the same way as LNG is today.
2) Lipták’s invention: the reversible fuel cell (RFC). The reversible fuel cell makes solar energy continuously available by making hydrogen when the sun is out and using it to make electricity when it is not.
3) The energy-free home with a roof covered with solar shingles, solar sidings and windows and provided with grid-connected two directional electric meters.

BIOGRAPHY: Mr. Lipták arrived from Hungary in the United States in 1956. In 1960, he became the Chief Instrument Engineer at C&R (later John Brown). In 1987, he was an adjunct professor at Yale University and he is currently working as a consultant with assistance (Lipták Associates PC) on industrial optimization. He has published two dozen technical books including: “Post-Oil Energy Technology”, “Optimization of Unit Operations” and “Environmental Engineers’ Handbook”.
Please join us for dinner. Advanced reservations recommended.

TBA
Dinner Meeting
Topic: “From Bench to the Clinic: Discovering and Development of Hepatitis C Virus Antivirals”
Speaker: David Olsen, PhD

Authors: ¹David Olsen,* ¹Steve Carroll, ²Larry Handt, ³Ken Koeplinger, ³Christine Fanzozi, ³Rena Zhang, ¹Donald Graham, 4Malcolm MacCoss, 4Nigel Liverton, 4John McCauley, 4Michael Rudd, 4Joseph Vacca, ¹Daria Hazuda, ¹Steven Ludmerer
Summary: Current therapies to treat hepatitis C virus (HCV) infection consist of combinations of pegylated interferon- and ribavirin which have significant side effects and are of limited utility in patients infected with HCV genotype 1, the most prevalent genotype in developed countries. Efforts to develop novel therapies with enhanced efficacy and tolerability have focused on direct antiviral agents targeting the virally encoded RNA polymerase, NS5B, and protease, NS3/4A. To develop an understanding of PK/PD relationships using an animal model of chronic infection, HCV-infected chimpanzees were administered MK-0608, an inhibitor of the HCV RNA polymerase, or MK-7009, a macrocyclic inhibitor of the HCV NS3/4A protease, at differing dose levels, durations, or routes of administration. Short-term administration of either MK-0608 or MK-7009 to HCV-infected chimpanzees resulted in profound viral load suppression. The results for MK-0608 indicated a steep PK/PD relationship, with a 10-fold difference in dose resulting in a 10,000-fold difference in viral load suppression. Dose-dependent differences in efficacy were also observed with MK-7009. Resistant viral variants were detected in rebounding viral populations in chimpanzees dosed with either compound. Over 3 logs of R155K variant resistant to MK-7009 was detected predose and persisted as a significant fraction of the circulating viral population far longer after cessation of dosing than did an S282T variant resistant to MK-0608, suggesting the R155K virus has a replication fitness similar to wild-type virus. The results of these studies regarding efficacy and potential for development of antiviral resistance have informed the strategy for clinical development of the compounds.

Footnotes: ¹Antiviral Research (WP), ²Laboratory Animal Research (WP), ³Drug Metabolism (WP), 4Medicinal Chemistry

BIOGRAPHY: David Olsen, Ph.D. has an undergraduate chemistry degree and trained as a biochemist at University of Maryland, College Park MD. David completed postdoctoral research at the Max-Planck Institute for Experimental Medicine (Göttingen, Germany) where he utilized chemistry, molecular biology and biochemical techniques to investigate structure/function of catalytic RNA. After completing his postdoctoral training, David joined the Antiviral Department at Merck in 1991.
David has more then 18 years of antiviral drug discovery and development experience with 59 publications. His career interests have focused on HIV-1 protease and reverse transcriptase and hepatitis C protease and polymerase inhibitory mechanisms. His other research interests include mechanisms of antiviral resistance and enzyme-nucleic acid interaction studies. In 2007 and 2008 David served as a Senior Director and Head of the Department of Antiviral Research in West Point Pennsylvania. In 2009 he transitioned to External Basic Research where he functions as the Site Lead for the Infectious Disease franchise.
In this new role, David expanded his area of drug discovery research to cover Merck’s external research pipeline in the areas of antibacterial, antifungal and antiviral research. His team is responsible for directing a dozen programs based in China, Japan, India and Russia.
Please join us for dinner. Advanced reservations recommended.

Snuffy’s Restaurant
Park and Mountain Ave. (off Route 22)
Scotch Plains, NJ 07076
Tel: 1-908-322-7726 www.weddingsatpantagis.com

Route 22 East : (Scotch Plains, Berkeley Heights, Fanwood, New Providence Exit) – Make a right turn at the exit (under overpass) and then go straight on Park Avenue for about 100 yards. Snuffy’s will be on the right. Route 22 West : (Scotch Plains, Berkeley Heights, Fanwood, New Providence Exit) – At the exit, make a right turn. At the traffic light, make a left turn and take the overpass over Route 22. At the end of the overpass, make a right onto Park Avenue. Snuffy’s will be on the right.

Garden State Parkway : (North and South) – Take Exit 140 from the Garden State Parkway and follow the signs for Route 22 West. Once on Route 22 West, follow the directions above.

Route 78 : (East and West) – Take Exit 41 from Route 78. Follow the signs to Scotch Plains. This will put you onto Plainfield Avenue. Follow Plainfield Avenue straight through the traffic light, where it becomes Bonnie Burn Road. Follow Bonnie Burn Road to the next traffic light and make a right turn (sign Scotch Plains/Newark). Follow the overpass over Route 22(traffic may back up here). At the end of the overpass, make a right onto Park Avenue. Snuffy’s will be on the right.

New Jersey Turnpike : (North and South) – Take Exit 14 from the New Jersey Turnpike and follow the signs to Route 78 West. Once on Route 78 West, follow the directions above.