Publications:

1. Mechanistic studies in the deoxygenation of pyridine N-oxide: new 1,2 elimination. Hwu, J.R.; Wetzel, J.M. (1985) Journal of Organic Chemistry 50(3), 400-2.
2. The trimethylsilyl cationic species as a bulky proton. Application to chemoselective dioxolanation. Hwu, J.R.; Wetzel, J.M. (1985) Journal of Organic Chemistry 50(20), 3946-8.
3. Calcium in liquid ammonia for the reduction of benzyl ethers. Mechanistic clues derived from chemoselectivity studies. Hwu, J.R.; Chua, V.; Schroeder, J.E.; Barrans, R.E., Jr.; Khoudary, K.P.; Wang, N.; Wetzel, J.M. (1986) Journal of Organic Chemisty 51(24), 4731-3.
4. General scope of 1,3-dioxolanation of alpha,beta-unsaturated aldehydes with 1,2-bis (trimethylsilyloxy) ethane and trimethylsilyl trifluoromethanesulfonate. Hwu, J.R.; Leu, L.C.; Robl, J.A.; Anderson, D.A.; Wetzel, J.M.. (1987) Journal of Organic Chemistry 52(2), 188-91.
5. Silicon-promoted ring contractions in the formation of carbocyclic spiro compounds. Total synthesis of (-)- solavetivone. Hwu, J.R.; Wetzel, J.M. (1992) Journal of Organic Chemistry 57 (3), 922-8.
6. Diversity in steroidogenesis of symbiotic microorganisms from planthoppers. Wetzel, J.M.; Ohnishi, M.; Fujita, T.; Nakanishi, K.; Naya, Y.; Noda, H.; Sugiura, M. (1992) Journal of Chemical Ecology 18(11), 2083-94.
7. Comparison of the electronic effect and the steric influence between the 1,1,2,2,2-pentamethyldisilanyl and the trimethylsilyl groups. Hwu, J.R.; Wetzel, J.M.; Lee, J.S.; Butcher, R.J. (1993) Journal of Organometallic Chemistry 453(1), 21-8.
8. The alpha1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha1c subtype. Forray, C.; Bard, J.A.; Wetzel, J.M.; Chiu, G.; Shapiro, E.; Tang, R.; Lepor, H.; Hartig, P.R.; Weinshank, R.L.; Branchek, T.A.; Gluchowski, C. (1994) Molecular Pharmacology 45(4), 703-8.
9. Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. Wetzel, J. M.; Miao, S.W.; Forray, C.; Borden, L.A.; Branchek, T.A.; Gluchowski, C. (1995) Journal of Medicinal Chemistry 38(10), 1579-81.
10. Fragmentation studies of ergosterol. The formation of the fragment ion at m/z 337. Kenney, P.T.M.; Wetzel, J.M. (1995) European Mass Spectrometry 1(4), 411-13.
11. Modeling and mutagenesis of the human alpha1a-adrenoceptor: orientation and function of transmembrane helix V sidechains. Wetzel, J.M.; Salon, J.A.; Tamm, J.A.; Forray, C.; Craig, D.; Nakanishi, H.; Cui, W.; Vaysse, P.J.-J.; Chiu, G.; Weinshank, R.L., Hartig, P.R., Branchek, T.A., Gluchowski, C. (1996)  receptors and Channels 4(3), 165-177.
12. Localization of mRNA and receptor binding sites for the alpha1a-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate. Walden, P.D.; Durkin, M.M.; Lepor, H.; Wetzel, J.M.; Gluchowski, C.; Gustafon, E.L. (1997) Journal of Urology (Baltimore) 157(3), 1032-1038.
13. Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues. O’Malley, S.S.; Chen, T.B.; Francis, B.E.; Gibson, R.E.; Burns, H.D.; DiSalvo, J.; Bayne, M.L.; Wetzel, J.M.; Nagarathnam, D.; Marzabadi, M.; Gluchowski, C.; Chang, R.S.L. (1998) European Journal of Pharmacology 348(2/3), 287-295.
14. Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate. Wong, W.C.; Chiu, G.; Wetzel, J.M.; Marzabadi,M.R.; Nagarathnam, D.; Wang, D.; Fang, J.; Miao, S.W.; Hong, X.; Forray, C.; Vaysse, P.J.J.; Branchek, T.A.; Gluchowski, C.; Tang, R.; Lepor, H. (1998) Journal of Medicinal Chemistry 41(14), 2643-2650.
15. Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia. Nagarathnam, D.; Wetzel, J.M.; Miao, S.W.; Marzabadi, M.R.; Chiu, G.; Wong, W.C.; Hong, X.; Fang, J.; Forray, C.; Branchek, T.A.; Heydorn, W.E.; Chang, R.S.L.; Broten, T.; Schorn, T.W.; Gluchowski, C. (1998) Journal of Medicinal Chemistry 41(26), 5320-5333.
16. Design and synthesis of novel dihydropyridine alpha-1A antagonists. Marzabadi, M.R.; Hong, X.;  agarathnam, D.; Miao, S.; Chiu, G.; Wong, W.C.; Wetzel, J.M.; Fang, J.; Forray, C.; Chen, T.B.; O’Malley, S.S.; Chang, R.S.L.; Gluchowski, C. (1999) Bioorganic & Medicinal Chemistry Letters 9(19), 2843-2848.
17. Design and synthesis of novel alpha1a adrenoceptor-selective antagonists. 4. Structureactivity relationship in the dihydropyrimidine series. Wong, W.C.; Sun, W.; Lagu, B.; Tian, D.; Marzabadi, M.R.; Zhang, F.; Nagarathnam, D.; Miao, S.W.; Wetzel, J.M.; Peng, J.; Forray, C.; Chang, R.S.L.; Chen, T.B.; Ransom, R.; O’Malley, S.; Broten, T.P.; Kling, P.; Vyas, K.P.; Zhang, K.; Gluchowski, C. (1999) Journal of Medicinal Chemistry 42(23) 4804-4813.
18. Design and synthesis of novel alpha1a adrenoceptor-selective antagonists. 1. Structureactivity relationship in dihydropyrimidinones. Nagarathnam, D.; Miao, S. Wu; Lagu, B.; Chiu, G.; Fang, J.; Dhar, T.G. Murali; Zhang, J.; Tyagarajan, S.; Marzabadi, M.R.; Zhang, F.; Wong, W.C.; Sun, W.; Tian, D.; Wetzel, J.M.; Forray, C.; Chang, R.S.L.; Broten, T.P.; Ransom, R.W.; Schorn, T.W.; Chen, T.B.; O’Malley, S.; Kling, P.; Schneck, K.; Bendesky, R.; Harrell, C.M.; Vyas, K.P.; Gluchowski, C. (1999) Journal of Medicinal Chemistry 42(23), 4764-4777.
19. Design and synthesis of novel alpha1a adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. Dhar, T.G.M.; Nagarathnam, D.; Marzabadi, M.R.; Lagu, B.; Wong, W.C.; Chiu, G.; Tyagarajan, S.; Miao, S.W.; Zhang, F.; Sun, W.; Tian, D.; Shen, Q.; Zhang, J.; Wetzel, J.M.; Forray, C.; Chang, R.S.L.; Broten, T.P.; Schorn, T.W.; Chen, T.B.; O’Malley, S.; Ransom, R.; Schneck, K.; Bendesky, R.; Harrell, C.M.; Vyas, K.P.; Zhang, K.; Gilbert, J.; Pettibone, D.J.; Patane, M.A.; Bock, M.G.; Freidinger, R.M.; Gluchowski, C. (1999) Journal of
Medicinal Chemistry 42 (23), 4778-4793.
20. De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. Lagu,B.; Tian, D.; Jeon, Y.; Li, C.; Wetzel, J.M.; Nagarathnam, D.; Shen, Q.; Forray, C.; Chang, R.S.L.; Broten, T.P.; Ransom, R.W.; Chan, T.-B.; O’Malley, S.S.; Schorn, T.W.; Rodrigues, A.D.; Kassahun, K.; Pettibone, D.J.; Freidinger, R.; Gluchowski, C. (2000) Journal of Medicinal Chemistry 43(15), 2775-2778.
21. Determination of the relative and absolute stereochemistry of a potent and alpha1Aselective adrenoceptor antagonist. Lagu, B.; Wetzel, J. M.; Forray, C.; Patane, M.A.; Bock, M.G.
(2000) Bioorganic & Medicinal Chemistry Letters 10(24), 2705-2707.
22. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini, J.A.; Jones, K.A.; Adham, N.; Forray, C.; Artymyshyn, R.; Durkin, M.M.; Smith, K.E.; Tamm, J.A.; Boteju, L.W.; Lakhlani, P.P.; Raddatz, R.; Yao, W.-J.; Ogozalek, K.L.; Boyle, N.; Kouranova, E.V.; Quan, Y.; Vaysse, P.J.; Wetzel, J.M.; Branchek, T.A.; Gerald, C.; Borowsky, B. (2000) Journal of Biological Chemistry 275(50), 39324-39331.
23. Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin- 1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists. Konkel, M.J.; Wetzel, J.M.; Cahir, M.; Craig, D.A.; Noble, S.A.; Gluchowski, C. (2005) Journal of Medicinal Chemistry 48(8), 3076-3079.
24. Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 1. The Discovery of Arylacetamides as Viable Replacements for the Dihydropyrimidinone Moiety of an HTS Hit. Jiang, Y.; Chen, C.-A.; Lu, K.; Daniewska, I.; De Leon, J.; Kong, R.; Forray, C.; Li, B.; Hegde, L.G.; Wolinsky, T.D.; Craig, D.A.; Wetzel, J.M.; Andersen, K.; Marzabadi, M. (2007) Journal of Medicinal Chemistry 50(16), 3870-3882.

25. Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 2: A Hybrid Strategy Combining Key Fragments of HTS Hits. Chen, C.-A.; Jiang, Y.; Lu, K.; Daniewska, I.; Mazza, C.G.; Negron, L.; Forray, C.; Parola, T.; Li, B.; Hegde, L.G.; Wolinsky, T.D.; Craig, D.A.; Kong, R.; Wetzel, J.M.; Andersen, K.; Marzabadi, M. (2007) Journal of Medicinal Chemistry 50(16), 3883-3890.

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