Education:

BS, Chemical Engineering. University of Michigan. 1993
Ph.D., Chemical Engineering. University of Massachusetts–Amherst. 1998

Posted in 9

Experience:

Previously Mike was Vice President of Engineering for LanzaTech.  During his six years with LanzaTech he led the scale-up and commercialization of first of its kind gas fermentation technology for conversion of waste carbon into fuel and chemical products. 

Prior to LanzaTech, Mike spent two years with Battelle Science and Technology Malaysia, where he worked closely with PETRONAS  to develop the R&D infrastructure and capabilities for a robust sustainable fuel and chemical portfolio.  This followed a ten year tenure at UOP in technology development.

Mike holds a B.S. in Chemical Engineering from the University of Michigan and a Ph.D. in Chemical Engineering from the University of Massachusetts.  He received the 2015 EPA Greener Synthetic Pathway award, and the 2005 Haden Freeman Award for Engineering Excellence from IChemE.  Mike has been granted more than 40 US Patents in his career.

Posted in 11

Patents and Publications:

44 US Patents.
Schultz, Michael A; Zhu, X. Xin; Qafisheh, Jabreel A. “Process and system for heating or cooling streams for a divided distillation column.” U.S. Patent 8,999,117. 07 April 2015.
Schultz, Michael A; Havill, Alice M; Oroskar, Anil R. “Fermentation and simulated moving bed process.” U.S. Patent 8,980,596. 17 March 2015.
Schultz, Michael A; Obern, James; Simpson, Sean D; “Methods and systems for the production of hydrocarbon products.” U.S. Patent 8,809,015. 19 Aug 2014.
Ulas Acikgoz, S; Schultz, Michael A; Zhu, X. X. “Process for recovering catalytic product.” U.S. Patent 8,747,654. 10 June 2014.
Schultz, Michael A. “Fermentation method.” U.S. Patent 8,663,949. 04 March 2014.
Schultz, Michael A; Griffin, Derek W. “Process for the production of esters.” U.S. Patent 8,658,402. 25 Feb 2014.
Jan, Deng-yang; Schultz, Michael A; and Johnson, James A. “Methods for removing unsaturated aliphatic hydrocarbons from a hydrocarbon stream using an acidic molecular sieve.” U.S. Patent 8,546,632. 01 Oct 2013.
Jan, Deng-yang; Schultz, Michael A; and Johnson, James A. “Methods for removing unsaturated aliphatic hydrocarbons from a hydrocarbon stream using activated carbon.” U.S. Patent 8,546,631. 01 Oct 2013.
Jan, Deng-yang; Schultz, Michael A; and Johnson, James A. “Methods for removing unsaturated aliphatic hydrocarbons from a hydrocarbon stream using clay.” U.S. Patent 8,546,630. 01 Oct 2013.
Schultz, Michael A and Zhu, Xin X. “Process for providing one or more streams.” U.S. Patent 8,518,245. 27 Aug 2013.
Jan, Deng-Yang and Schultz, Michael A. “Selective hydrogenation of unsaturate aliphatic hydrocarbons in predominantly aromatics streams.” U.S. Patent 8,350,106. 08 Jan 2013.
Glover, Bryan K.; Zarraga, Julie A.; and Schultz, Michael A. “Fluidized bed reactor with back-mixing for dehydrogenation of light paraffins.” U.S. Patent 8,282,886. 9 Oct 2012.
Schultz, Michael A. and Zhu, Xin. “Zone or system for providing one or more streams.” U.S. Patent 8,246,816. 21 Aug 2012.
Schultz, Michael A., Zhu, Xin, and Qafisheh, Jibreel. “Process and system for heating or cooling streams for a divided distillation column.” U.S. Patent 8,197,677. 12 June 2012.
Schultz, Michael A. “Integrated production of FCC-produced C3 and cumene.” U.S. Patent 8,128,895. 6 March 2012.
Vora, Bipin., Luebke, Charles., Meister, Jill. Schultz, Michael A., and Shields, Dale. “Process and apparatus for oligormerization in multiple stages with single fractionation column.” U.S. Patent 8,052,945. 8 Nov 2011.
Schultz, Michael A.; Wegerer, David A.; and Towler, Gavin. “Modified absorption recovery processing of fcc-produced light olefins.” U.S. Patent 8,007,661. 30 Aug 2011.
Towler, Gavin; Brady, John; Lechnick, W. Jay; and Schultz, Michael A. “Fractionation recovery processing of light olefins free of carbon dioxide.” U.S. Patent 7,973,209. 5 July 2011.
Schultz, Michael A. “Dividing wall separation in light olefin hydrocarbon processing.” U.S. Patent 7,947,860. 24 May 2011.
Schultz, Michael A. “Integrated production of FCC-produced C2 and ethyl benzene.” U.S. Patent 7,914,754. 29 March 2011.
Glover, Bryan K; Zarraga, Julie A; and Schultz, Michael A. “Fluidized bed reactor with back-mixing for dehydrogenation of light paraffins.” U.S. Patent 7,902,416. 8 March 2011.
Vora, Bipin., Luebke, Charles., Meister, Jill. Schultz, Michael A., and Shields, Dale. “Process and apparatus for oligormerization in multiple stages with single fractionation column.” U.S. Patent 7,803,978. 28 Sept 2010.
Schultz, Michael A. “Integrated production of FCC-produced C3 and cumene.” U.S. Patent 7,795,486. 14 Sept 2010.
Schultz, Michael A. “Integrated production of FCC-produced C2 and ethyl benzene.” U.S. Patent 7,795,485. 14 Sept 2010.
Schultz, Michael A. “Modified fractionation recovery processing of FCC-produced light olefins.” U.S. Patent 7,763,165. 27 July 2010.
Schultz, Michael A. and Corroadi, Jason. “Fractionation recovery processing of FCC-produced light olefins.” U.S. Patent 7,737,317. 15 June 2010.
Naunheimer, Chris; Sechrist, Paul; and Schultz, Michael A. “Enhanced bed separation in a styrene monomer reaction using milled plates.” U.S. Patent 7,718,146. 18 May 2010.
Schultz, Michael A., Lankton, Steven P., and Tagamolila, Constante. “Apparatus for producing ethylbenzene or cumene.” U.S. Patent 7,713,386 B2. 11 May 2010.
Schultz, Michael A. ,Towler, Gavin; Brady, John; and Lechnick, W. Jay; “Amine treatment in light olefin processing.” U.S. Patent 7,687,048. 30 March 2010.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing cumene.” U.S. Patent 7,525,006 B2. 28 April 2009.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing ethylbenzene.” U.S. Patent 7,525,003 B2. 28 April 2009.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing ethylbenzene.” U.S. Patent 7,525,004 B2. 28 April 2009.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing cumene.” U.S. Patent 7,525,005 B2. 28 April 2009.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing cumene.” U.S. Patent 7,498,471 B2. 3 March 2009.
Schultz, Michael A.; Lankton, Stephen P., and Tagamolila, Constante. “Process for producing ethylbenzene.” U.S. Patent 7,498,472 B2. 3 March 2009.
Schultz, Michael A. and Brady, John P. “Process for the removal of sulfur-oxidated compounds from a hydrocarbon stream.” U.S. 7,452,459. 11 Nov 2008.
Schultz, Michael A. and Maher, Greg F. “Process for making xylene isomer using a deheptanizer with a side draw recycle.” U.S. Patent 7,371,912. 13 May 2008.
James W. Harris, Steven P. Rosenblum, Michael A. Schultz, Dennis E. O’Brien, and Douglas G. Stewart, “Dividing wall distillation column control apparatus.” U.S. Patent 7,267,746. 11 September 2007.
Schultz, Michael A, Gatan, Ronald M., Brandvold, Timothy A., and Gosling, Christopher D., “Process for the regeneration of an adsorbent bed containing sulfur oxidated compounds.” U.S. Patent 7,186,328. 6 March 2007.
Hayim Abrevaya, Joel T. Walenga, Michael A. Schultz, and Anil R. Oroskar, “Riser reactor system for hydrocarbon cracking.” U.S. Patent 7,112,307. 26 September 2006.
Schultz, Michael A. and Weiszmann, Joseph W. “Fractionation and treatment of full boiling range gasoline.” U.S. Patent 6,927,314. 9 August 2005.
Hayim Abrevaya, Joel T. Walenga, Michael A. Schultz, and Anil R. Oroskar, “Riser reactor system for hydrocarbon cracking.” U.S. Patent 6,791,002. 14 September 2004.
Gavin P. Towler and Michael A. Schultz, “Fractionation for full boiling range gasoline desulfurization.” U.S. Patent 6,726,835. 27 April 2004.
Gavin P. Towler and Michael A. Schultz, “Fractionation for full boiling range gasoline desulfurization.” U.S. Patent 6,540,907. 1 April 2003.

Publications
Schultz, Michael A. “A Hierarchical Decision Procedure for the Conceptual Design of Pollution Prevention Alternatives for Chemical Processes.” 1 Jan. 1998. (Doctoral Dissertations Available from Proquest. Paper AAI9909218.)
Schultz, Michael A., Douglas, James M. “The Effect of Heat Carrier Selection on the Structure of a Flowsheet”, Industrial & Engineering Chemistry Research, Vol. 39, No. 6, June 2000, pp. 1878-1890.
Schultz, Michael A., Douglas, James M. “Stream Costs-A First Screening of Reaction Pathways”, Industrial & Engineering Chemistry Research, Vol. 39, No. 7, July 2000, pp.2410-2417.
O’Brien, Dennis E., Schultz, Michael A., Stewart, Douglas G., Harris, James W., Rosenblum, Steven P., Shakur, Mohammed S. “Reduce Costs with Dividing-Wall Columns”, Chemical Engineering Progress, Vol. 98, No. 5, May 2002, pp. 64-71.
O’Brien, Dennis E., Schultz, Michael A. “Ask the Experts: How Can I Design an Optimized Distillation Column?”, Chemical Engineering Progress, Vol. 100, No. 2, February 2004, pp. 14.
Schultz, Michael A., et al. “Innovative flowschemes using dividing wall columns.” Computer Aided Chemical Engineering 21 (2006): 695-700.
Griffin, Derek W., Schultz, Michael A. “Fuel and chemical products from biomass syngas: a comparison of gas fermentation to thermochemical conversion routes.” Environmental Progress & Sustainable Energy 31.2 (2012): 219-224.
Fleischanderl, A, Platner, T., Puschitz, P. ,Nair, P., and Schultz, M. “The Circular Economy: Carbon Recycling and the Steel Industry”, Steel & Metallurgy, Jan 2016.
Schultz, Michael A. “Classical Chemical Technology Wins Role in Bioprocessing”, Chemical Processing, Aug 2017, pp 37-41. https://www.chemicalprocessing.com/articles/2017/classical-chemical-technology-wins-role-in-bioprocessing/
Presentations:
“Design and Control of a Dividing Wall Column for the PacolTM Enhancement Process (PEPTM)”
AIChE National Meeting | Spring 2001
“Fractionator Process Design Overview”
Spring AIChE National Meeting | Spring 2002
“Advanced Yield Estimating Tools Linking Multiple Types of Models”
Spring AIChE National Meeting | Spring 2003
“Process Design Software Needs for the Refining and Petrochemical Industries”
AIChE National Meeting | Spring 2003
“Dividing Wall Columns at UOP: From Development to Commercial Reality”
IChemE Symposium on Dividing Wall Columns | September 2004
“Innovative Process Flowschemes Using Advanced Fractionation Techniques”
AIChE National Meeting | Fall 2005
“Innovative Flowschemes Using Dividing Wall Columns”
ESCAPE-16 + PSE ‘2006, Garmisch-Partenkirchen Germany
“Process Applications for New EBZ-800 Alkylation Catalyst”
International Styrene Conference | Hong Kong | 2006
“New Catalyst and Process Innovations for Cumene Alkylation”
AIChE Meeting | Spring 2007
“Fuel and Chemical Products from Biomass Syngas”
tcbiomass | 2011
“Fuels and Chemicals from Industrial Gases”
ChemInnovations | 2011
“LanzaTech Overview: Technology Development and Commercialization”
SBE Conference on Electrofuels Research | 2011
“Bringing Value to Waste Through Gas Fermentation”
AIChE Meeting | Spring 2011
“Gas Fermentation of Industrial Waste Gases to Fuel and Chemicals”
AIChE Annual Meeting | 2011
“Completing the Cycle: Capturing Waste Carbon As Fuel/Chemicals”
AIChE Annual Meeting | 2011
“LanzaTech: Gas to Liquids via Gas Fermentation”
Prospects for North American Gas To Liquids | 2012
“Develop the Right Innovative Concepts Using Early Stage Process Design”
Process Development Symposium | 2012
“Hybrid Thermochemical/Biochemical Gas Fermentation Process for Production of Fuels and Chemicals”
AIChE Annual Meeting | 2012
“Commercializing Gas Fermentation”
5th Annual AIChE Midwest Regional Conference | 2013
“Conversion of Steel Mill Gases to Fuels and Chemicals”
AISTech | 2013
“LanzaTech Projects and Technology for Advanced Biofuels and Chemical Co-Products”
AIChE Annual Meeting | 2013
“CO2 and CO Fermentation: A Route from Waste to Fuels and Chemicals”
GTL Technology Forum | 2014
“Reproducing Results from R&D Scale to Industrial Scale”
Technology Challenges and Opportunities in Commercializing Industrial Biotechnology | 2015
“Fuel and Chemical Products from Biomass Syngas”
tcbiomass | 2015
“Moving Towards a Low Carbon Future”
Plenary Presentation – GLCACS | 2016
“Carbon recycling from metallurgical waste gases into bio-fuel and chemicals”
SCANMET V: 5th International Conference on Process Development in Iron and Steelmaking | 2016
“Using the Best of Biology and Chemistry for Sustainable Solutions” AIChE Midwest Regional Conference | 2017
“Scale Down…To Scale Up More Efficiently” AIChE Process Development Symposium | 2017

Posted in 14

Specializing In:

Specific services provided include the following categories:

1)  Pharmaceutical project management leadership

2)  API evaluation, practical design, development and optimization

3)  CM&C program leadership and regulatory affairs

4)  Medicinal chemistry and process chemistry SAR development interface

5) Process chemistry synthesis design, development and optimization stewardship

6)  Synthesis interface with engineering, analytical chemistry and manufacturing

7) Regulatory oversight with IND, NDA (FDA, EMA and global regulatory agencies)

8)  CMO selection, relationship oversight and general management

9)  Due diligence for partnering or acquisition of pharmaceutical products

10) Academic, government and professional societies scientific collaboration

11)  Expert witness for litigation in the legal profession

Posted in 6

Society Memberships:

American Chemical Society
Chemical Consultants Network

Posted in 8

Patents and Publications:

Issued PATENTS
19] US7034045 B1, Bender, D. M., Cantrell, B.E., Fray, A. H, Jones, W. D., Miller, W. D, Mitchell, D., Simon, R. L., Zarrinmayeh, H., Zimmerman, D. M.; Monofluoroalkyl Derivatives, April 26, 2006.
18] EP1353910A2, Koenig, Thomas; Audia, James; Mitchell, David; Mcdaniel, Stacey; Lactam Compounds, October 22, 2003.
17] EP1345955, Koenig, T. M.; Mitchell, D.; Nissen, J. S. Lactam Dipeptide and its use in Inhibiting Beta-Amyloid Peptide, September 24, 2003.
16] WO 0240508 A2, Koenig, Thomas; Mitchell, David; Nissen, Jeffrey; Lactam Compounds, May, 2002.
15] WO0240451 A2, Koenig, Thomas; Audia, James; Mitchell, David; McDaniel, Stacey; Buccilli; Lynne; Engel, Gary; Nissen, Aikins, James; Lactam Compounds, May, 2002.
14] EP1183232, Bender, D. M.; Cantrell, B. E.; Fray, A. H.; Jones, W. D.; Miller, W. D.; Mitchell, D.; Simon, R, L.; Zarrinmayeh, H.; Zimmerman, D., Monofluoroalkyl Derivatives, March 6, 2002.
13] WO0068182, Brennan, J.; Diseroad, W.; Hay, L.; Mitchell, D.; Process for Crystallizing (R) Fluoxetine Hydrochloride, November 16, 2000.
12] WO0066546, Bender, D. M.; Cantrell, B. E.; Fray, A. H.; Jones, W. D.; Miller, W. D.; Mitchell, D.; Simon, R, L.; Zarrinmayeh, H.; Zimmerman, D., Monofluoroalkyl Derivatives, November 9, 2000.
11] WO0064855; Koenig, Thomas; Mitchell, David; Epimerization Reaction for the Production of R-Fluoxetine, November 2, 2002.
10] US06,069,247, Lynne A. Hay, David Mitchell, Eli Lilly and Company, Process for Preparing Substituted Acrylamides. 2000.
9] EP0944581A1, Hay, Lynne; Mitchell, David; Process for Preparing Substituted Acrylamides, September 29, 1999.
8] US05,917,038A1, Lynne A. Hay, David Mitchell, Eli Lilly and Company, Process for Preparing Substituted Acrylamides. June 29, 1999.
7] WO9822429A1, Hay, Lynne; Mitchell, David; Process for Preparing Substituted Acrylamides, May 28, 1998.
6] US005250571, Ray W. Fuller, David Mitchell, David W. Robertson, Gregory A. Stephenson, David Wong, Eli Lilly and Company, (S)-Norfluoxetine in Method of Inhibiting Serotonin Uptake, September 5,1993.
5] JP05092946A, David Mitchell, Eli Lilly and Company, Regioselective Synthesis, April 16, 1993.
4] JP05078302A, David Mitchell, Eli Lilly and Company, Synthesis of B-Cyanohydrin, March 30, 1993.
3] US005136079A, David Mitchell, Eli Lilly and Company, Regioselective Synthesis, 1992.
2] US005136078A, David Mitchell, Eli Lilly and Company, Synthesis of B-Cyano-hydrin, 1992
1] EP 444855 A1 19910904. Fuller, Ray Ward; Mitchell, David; Robertson, David Wayne; Stephenson, Gregory Alan; Wong, David Taiwai. Novel crystalline forms of (S)-norfluoxetine hydrochloride, February 26, 1991.
PUBLICATIONS (selected)
49] Lu, Y.; Cole, K. P.; Fennell, J. W.; Maloney, T. D.; Mitchell, D.; Subbiah, R.; Ramadas, B. “An Alternative Indazole Synthesis for Merestinib.” Org. Process Res. Dev. 2018, 22 (3), 409-419.
48] Mitchell, D. “Synthesis of LY2623091. Highlights in Chemical Synthesis.” Synfacts, 2017, 13, 449-562.
47] Hansen, M. M.; Kallman, N. J.; Koenig, T. M.; Linder, R. J.; Richey, R. N.; Rizzo, J. R.; Ward, J. A.; Yu, H.; Zhang, T. Y.; Mitchell, D. “An Efficient Synthesis Process for MR Antagonist LY2623091.” Org. Process Res. Dev. 2017, 21(2), 208-217.
46] Risley, D. S.; Chaddha, R.; Mitchell, D. “Retention, direct detection, and quantitation of palladium (II) using high-performance liquid chromatography and evaporative light scattering detection.” J. Liq. Chromatogr. Related. Technol. 2017, accepted version posted on line August 4, (DOI: 10.1080/10826076.2017.1360907).
45] Cole, K. P.; Groh, J. M.; Johnson, M. D.; Burcham, C. L.; Campbell, B. M.; Diseroad, W. D.; Heller, M. R.; Howell, J. R.; Kallman, N. J.; Koenig, T. M.; May, S. A; Miller, R. D.; Mitchell, D.; Myers, D. P.; Myers, S. S.; Phillips, J. P.; Polster, C. S.; White, T. D.; Cashman, J.; Hurley, D.; Moylan, R.; Sheehan, P.; Spencer, R. D.; Desmond, K.; Desmond, P.; Gowran, O. “Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow
CGMP conditions.” Science, 2017, 356(6343), 1144-1150.
44] Sharif, S.; Day, J.; Hunter, H. N.; Lu, Y.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “Cross-coupling of primary amides to aryl- and heteroaryl-partners using (DiMeIHeptCl)Pd promoted by trialkylboranes or BCF.” J. Am. Chem. Soc. 2017, ASAP (Web 16 Oct 2017).
43] Khadra, A.; Mayer, S.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “A General Protocol for the Broad-Spectrum Cross-Coupling of Nonactivated Sterically Hindered 1° and 2° Amines.” Organometallics 2017, 36(17), 3365-3370.
42] Lombardi, C.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “Pd-PEPPSI-IPentCl-Catalyzed Amination Using Aminotriphenylsilane as an Ammonia Surrogate.” European Journal of Organic Chemistry, 2017, 11, 1510-1513.
41] Lombardi, C.; Day, J.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Farmer, J. L.; Organ, M. G. “Selective Cross-Coupling of (Hetero)aryl Halides with Ammonia To Produce Primary Arylamines using Pd-NHC Complexes.” Organometallics, 2017, 36(2), 251-254.
40] Organ, M. G.; Sharif, S.; Mitchell, D.; Rodriguez, M.; Farmer, J. L. A. “N-Heteroarylation of Optically Pure α-Amino Esters using the Pd-PEPPSI-IPentCl-o-picoline Pre-catalyst.” Chemistry – A European Journal 2016, 22(42), 14860-14863.
39] Organ, M. G.; Atwater, B.; Rodriguez, M. J.; Chandrasoma, N.; Mitchell, D. “Pd-PEPPSI-IHeptCl: A General Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs.” Chemistry – A European Journal, 2016, 22(41), 14531-14534.
38] Kallman, N. J.; Cole, K. P.; Koenig, T. M.; Buser, J. Y.; McFarland, A. D.; McNulty, L. M.; Mitchell, D. “Synthesis of Aminopyrazoles from Isoxazoles: Comparison of Preparative
Methods by in situ NMR Analysis.” Synthesis, 2016, 48, 3537-3543.
37] Cole, K. P.; Campbell, B. M.; Forst, M. B.; McClary G. J.; Hess, M.; Johnson, M. D.; Miller, R. D.; Mitchell, D.; Polster, C. S.; Reizman, B. “An Automated Intermittent Flow Approach to Continuous Suzuki Coupling.” Org. Process Res. Dev. 2016, 20(4), 820-830.
36] Sharif, S.; Rucker, R. P.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Froese, R. D. J.; Organ, M. G. “Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst.” Angew. Chem. Int. Ed. 2015, 54 (33), 9507-9511.
35] Atwater, B.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Pompeo, M.; Froese, R. D. J.; Organ, M. G. “The Selective Cross-Coupling of Secondary Alkyl Zinc Reagents to Five-Membered-Ring Heterocycles Using Pd-PEPPSI-IHept(Cl).” Angew. Chem. Int. Ed. 2015, 54 (33), 9502-9506.
34] Deasy, R. E.; Slattery, C. N.; Kissane, M.; McNamara, O. A.; Lynch, D.; Maguire, A. R.; Moynihan, H. A.; O’Keeffe, S.; Kopach, M. E.; Mitchell, D.; Magnus, N. A.; Kjell, D. P.; Moher, E. D. “Leveraging an Industrial-Academic Partnership To Optimize Small Molecule Process Development within the Pharmaceutical Industry.” Org. Process Res. Dev. 2015, 19 (2), 344-346.
33] Mitchell, D.; Luo, Y.; McNulty, L. M.; Buser, J. Y.; McFarland, A. D. “A Convenient and Practical Synthesis of Aminopyrazole.” Synthesis, 2015, 47, 235-241.
32] Ritter, S. K. interview with D. Mitchell. “Living Up to the Process Challenge.” Chem. Eng. News. 2014, 93(12), 30-33.
31] Grainger, D. M.; Zanotti-Gerosa, A.; Cole, K. P.; Mitchell, D.; May, S. A.; Pollock, P. M.; Calvin, J. R. “Development of a Stepwise Reductive Deoxygenation Process by Ru-Catalyzed Homogeneous Ketone Reduction and Pd-Catalysed Hydrogenolysis in the Presence of Cu Salts.” ChemCatChem. 2013, 5, 1205-1210.
30] Campbell, A. N.; Cole, K. P.; Martinelli, J. R.; May, S. A.; Mitchell, D.; Pollock, P. M.; Sullivan, K. A. “Development of an Alternate Synthesis for a Key JAK2 Inhibitor Intermediate via Sequential C-H Bond Functionalization.” Org. Process Res. Dev. 2013, 17(2), 273-281.
29] Kissane, M.; McNamara, O. A.; Mitchell, D.; Coppert, D. M.; Humphrey, M. A.; Lorentz, K. T.; Maguire, A. R. “Expanded scope of heterocyclic biaryl synthesis via a palladium-catalysed thermal decarboxylative cross-coupling reaction.” Tetrahedron Lett. 2012, 53 (4), 403-405.
28] Mitchell, D.; Cole, K. P.; Pollock, P. M.; Coppert, D. M.; Burkholder; T. P.; Clayton, J. R. “Development and a practical Synthesis of the JAK2 Inhibitor LY2784544.” Org. Process Res. Dev. 2012, 16 (1), 70-81.
27] Mitchell, D.; Coppert, D.; Moynihan, H. A.; Lorenz, K. T; Kissane, M.; McNamera, O. A.; Maguire, A. R. “A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature.” Org. Process Res. Dev. 2011, 15, 981-985.
26] Halford, B. (with Mitchell, D.) “From a Teaspoon to a Ton,” Chem. Eng. News. 2010, 88(36), 17-28.
25] Cole, K. P.; Mitchell, D. Carr, M. A.; Stout, J. R; Belvo, M. D. “Synthesis and axial chirality of an enantiopure aminodibenzazepinone.” Tetrahedron: Asymmetry, 2009, 20(11), 1262-1266.
24] Boini, S. K.; Vaid R. K.; Mitchell, D.; Moder, K. P. “Synthesis of a substituted benzazepin-2-one dehydrate.” Synthesis, 2009, 12, 1983-1986.
23] Yates, M. H.; Koenig, T. M.; Kallman, N. J.; Ley, C. P.; Mitchell, D. “An Efficient Synthesis of a Multipotent Eicosanoid Pathway Modulator.” Org. Process Res. Dev. 2009, 13(2), 268-275.
22] Pu, Y. J.; Vaid, R. K.; Boini, S. K.; Towsley, R. W.; Doecke, C. W.; Mitchell, D. “A practical method for functionalized peptide or amide bond formation in aqueous-ethanol media with EDC as activator.” Org. Process Res. Dev. 2009, 13(2), 310-314.
21] Xie, C.; Sullivan, K.; Pu, J.; Mitchell, D. “Selective Monoarylation of Benzenediols via Dianion Intermediates.” Syn. Comm. 2008, 38, 21-32.
20] Zhang, F.; Mitchell, D.; Pollock, P.; Zhang, T. “Efficient synthesis of 3-oxygenated benzothiophene derivatives.” Tetrahedron Lett. 2007, 48, 2349-2352.
19] Yu, Y.; Stephenson, G. A.; Mitchell, D. “Benzoazepinone Synthesis: Seven Membered Ring Formation by Palladium-Catalyzed Cyclization of Alkynyl Benzeneacetamides.” Tetrahedron. Lett. 2006, 47, 3811-3814.
18] Wan, Z.; Jones, C. D.; Mitchell, D.; Pu, J. Y.; Zhang, T. Y. “Practical Method for Transforming Alkynes into -Diketones.” J. Org. Chem. 2006, 71(2), 826-828.
17] Mitchell, D.; Audia, J. A.; Buccilli, L. A.; Koenig, T. M.; McDaniel, S, L.; Nissen, J. S. “Dynamic and Chemical Resolution of Aminobenzoazepinone.” Tetrahedron: Asymmetry, 2005, 16, 3814-3819.
16] Mitchell, D.; Yu, H. “Synthetic Application of Palladium-Catalyzed Hydroarylation and Related Systems” Current Opinion in Drug Discovery and Development, 2003, 6(6), 876-883.
15] Wan, Z.; Jones, D. C; Koenig, T. M.; Pu, Y. J.; Mitchell, D.; “Vinyl Aryl Ethers from Copper-Catalyzed Coupling of Vinyl Halides and Phenols.” Tetrahedron Lett. 2003, 44, 8257-8259.
14] Godfrey, A. G.; Brooks, D. A.; McCarthy, J.; Hay, L. A.; Wepsiec, J.; Peters, M.; Mitchell, D. “Application of the Dakin-West Reaction for the Synthesis of Oxazole-Containing Dual PPAR a/g agonist.” J. Org. Chem. 2003, 68, 2623-2632.
13] Robbins, D. K.; Dodson, P. N.; Buccilli, L. A.; Mitchell, D. “Utilizing Capillary Gas Chromatography Mass Spectrometry to Determine 4-Benzotrifluoride t-Butyl Ether as a Reaction By-Product in Fluoxetine Synthesized using Potassium t-Butoxide as Base.” J. Pharm. Biomed. Anal. 2003, 31(1), 63-74.
12] Mitchell, D. “ From Bench Top Research to Pilot-Plant Production and Process Research in the Pharmaceutical Industry.” (ACS Volume, Book Chapter). September 15, 2000.
11] Hay, L. A.; Koenig, T. M.; Ginah, F. O.; Copp, J. D.; Mitchell, D. “Palladium-Catalyzed Hydroarylation of Propiolamides. A Regio- and Stereocontrolled Method for Preparing 3,3-Diaryl Acrylamides.” J. Org. Chem. 1998, 63, 15, 5050-5058.
10] Hay, L. A.; Mitchell, D. “A Regio- and Stereocontrolled Method for Preparing 3,3-Diaryl Acrylamides.” Tetrahedron Lett. 1997, 38, 6533-6536.
9] Huff, B. E.; Koenig, T. M.; Mitchell, D.; Staszak, M. A. “Synthesis of Unsymmetrical Biaryls Using a Modified Suzuki Cross-Coupling: 4-Biphenylcarbox-aldehyde ([1,1’-Biphenyl]-4-Carboxaldehyde).” Organic Syntheses, 1997, 75, 53-60.
8] Mitchell, D.; Doecke, C. W.; Hay, L. A.; Koenig, T. M.; Wirth, D. D. “Ortho-Hydroxyl Assisted Deoxygenation of Phenones. Regiochemical Control in the Synthesis of Monoprotected Resorcinol and Related Systems.” Tetrahedron Lett. 1995, 36(30), 5335-5338.
7] Mitchell, D.; Koenig, T. M. “Synthesis of R- and S- Fluoxetine, Norfluoxetine and Related Compounds from Styrene Oxide.” Synthetic Commun. 1995, 25(8), 1231-1238.
6] T. M. Koenig and D. Mitchell, “A Convenient Method for Preparing Enantiomerically Pure Norfluoxetine, Fluoxetine and Tomoxetine.” Tetrahedron Lett. 1994, 35(9), 1339-1342.
5] Mitchell, D.; Koenig, T. M. “Regiospecific Opening of 1,2 Epoxides with Acetone Cyanohydrin under Mildly Basic Conditions.” Tetrahedron Lett. 1992, 33(23), 3281-3284.
4] Mitchell, D.; Liebeskind, L. S. “Benzoabikoviromycin, a Potential Antiviral Agent Synthesized by the Palladium-Catalyzed Ring Expansion of 2-Alkynyl-2-hydroxybenzocyclobutenones.” J. Am. Chem. Soc. 1990, 112(1), 291-296.
3] Mitchell, D. “Transition Metal Organometallics in the Synthesis of Biologically Active Molecules: Alkylidene Indianones and Quinines.” Ph.D. Thesis, Emory University, Atlanta, GA, Advisor: Lanny S. Liebeskind, 1989.
2] Liebeskind, L. S.; Chidambaram, R.; Mitchell, D.; Foster, B. “Metal Mediated Route to 5-Membered Rings.” Pure and Applied Chemistry 1988, 60(1), 27-34.
1] Liebeskind, L. S.; Mitchell, D.; Foster, B. “A Stereoselective Palladium
Catalyzed Route to 4-Oxygenated 5-Alkylidene Cyclopentadienes and 3-Oxygenated-2-Alkylidene Indenones.” J. Am. Chem. Soc. 1987, 109(25), 7908-7910.

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Industrial Experience:

DMIT Consulting Services, LLC; Naples, Florida. Established 2018, Principal

Eli Lilly and Company, Indianapolis, IN.  Small Molecules Design and Development.  Research Advisor (2004 – 2017); Senior Research Scientist (1998-2004), Research Scientist (1994-1998), Senior Organic Chemist (1989-1994). Primary duties include the design and development of synthesis methodology for pharmaceutical products from discovery to commercial manufacturing. (28 years)

Procter and Gamble Company, Miami Valley, Ohio. Summer Intern. Assisted in the improvement of the potato chip flavor of a particular salted snack.  Summer Intern, 1984. (10 weeks)

Burroughs Wellcome Company, Research Triangle Park, NC.  Summer Intern. Design new method in the multigram synthesis of a drug to be used in early phase clinical trials.  Summer Intern, 1983. (10 weeks)

Hess Oil Company, St. Croix, US Virgin Islands. Quality Control Laboratory. Apprentice. Responsibilities included the application of basic qualitative tests used in oil refinery.  CoOp and Summer Intern, 1980. (2 years)

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Education:

Emory University, Atlanta, GA, 1984 to 1988, Ph.D.
N. C. Central Univ, Durham, NC, 1980 to 1984, BS

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Education

B Che- Georgia Institute of Technology

MS Che- Rutgers University

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Trade Associations

The American Institute of Chemical Engineers

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