Patents and Publications:

Issued PATENTS
19] US7034045 B1, Bender, D. M., Cantrell, B.E., Fray, A. H, Jones, W. D., Miller, W. D, Mitchell, D., Simon, R. L., Zarrinmayeh, H., Zimmerman, D. M.; Monofluoroalkyl Derivatives, April 26, 2006.
18] EP1353910A2, Koenig, Thomas; Audia, James; Mitchell, David; Mcdaniel, Stacey; Lactam Compounds, October 22, 2003.
17] EP1345955, Koenig, T. M.; Mitchell, D.; Nissen, J. S. Lactam Dipeptide and its use in Inhibiting Beta-Amyloid Peptide, September 24, 2003.
16] WO 0240508 A2, Koenig, Thomas; Mitchell, David; Nissen, Jeffrey; Lactam Compounds, May, 2002.
15] WO0240451 A2, Koenig, Thomas; Audia, James; Mitchell, David; McDaniel, Stacey; Buccilli; Lynne; Engel, Gary; Nissen, Aikins, James; Lactam Compounds, May, 2002.
14] EP1183232, Bender, D. M.; Cantrell, B. E.; Fray, A. H.; Jones, W. D.; Miller, W. D.; Mitchell, D.; Simon, R, L.; Zarrinmayeh, H.; Zimmerman, D., Monofluoroalkyl Derivatives, March 6, 2002.
13] WO0068182, Brennan, J.; Diseroad, W.; Hay, L.; Mitchell, D.; Process for Crystallizing (R) Fluoxetine Hydrochloride, November 16, 2000.
12] WO0066546, Bender, D. M.; Cantrell, B. E.; Fray, A. H.; Jones, W. D.; Miller, W. D.; Mitchell, D.; Simon, R, L.; Zarrinmayeh, H.; Zimmerman, D., Monofluoroalkyl Derivatives, November 9, 2000.
11] WO0064855; Koenig, Thomas; Mitchell, David; Epimerization Reaction for the Production of R-Fluoxetine, November 2, 2002.
10] US06,069,247, Lynne A. Hay, David Mitchell, Eli Lilly and Company, Process for Preparing Substituted Acrylamides. 2000.
9] EP0944581A1, Hay, Lynne; Mitchell, David; Process for Preparing Substituted Acrylamides, September 29, 1999.
8] US05,917,038A1, Lynne A. Hay, David Mitchell, Eli Lilly and Company, Process for Preparing Substituted Acrylamides. June 29, 1999.
7] WO9822429A1, Hay, Lynne; Mitchell, David; Process for Preparing Substituted Acrylamides, May 28, 1998.
6] US005250571, Ray W. Fuller, David Mitchell, David W. Robertson, Gregory A. Stephenson, David Wong, Eli Lilly and Company, (S)-Norfluoxetine in Method of Inhibiting Serotonin Uptake, September 5,1993.
5] JP05092946A, David Mitchell, Eli Lilly and Company, Regioselective Synthesis, April 16, 1993.
4] JP05078302A, David Mitchell, Eli Lilly and Company, Synthesis of B-Cyanohydrin, March 30, 1993.
3] US005136079A, David Mitchell, Eli Lilly and Company, Regioselective Synthesis, 1992.
2] US005136078A, David Mitchell, Eli Lilly and Company, Synthesis of B-Cyano-hydrin, 1992
1] EP 444855 A1 19910904. Fuller, Ray Ward; Mitchell, David; Robertson, David Wayne; Stephenson, Gregory Alan; Wong, David Taiwai. Novel crystalline forms of (S)-norfluoxetine hydrochloride, February 26, 1991.
PUBLICATIONS (selected)
49] Lu, Y.; Cole, K. P.; Fennell, J. W.; Maloney, T. D.; Mitchell, D.; Subbiah, R.; Ramadas, B. “An Alternative Indazole Synthesis for Merestinib.” Org. Process Res. Dev. 2018, 22 (3), 409-419.
48] Mitchell, D. “Synthesis of LY2623091. Highlights in Chemical Synthesis.” Synfacts, 2017, 13, 449-562.
47] Hansen, M. M.; Kallman, N. J.; Koenig, T. M.; Linder, R. J.; Richey, R. N.; Rizzo, J. R.; Ward, J. A.; Yu, H.; Zhang, T. Y.; Mitchell, D. “An Efficient Synthesis Process for MR Antagonist LY2623091.” Org. Process Res. Dev. 2017, 21(2), 208-217.
46] Risley, D. S.; Chaddha, R.; Mitchell, D. “Retention, direct detection, and quantitation of palladium (II) using high-performance liquid chromatography and evaporative light scattering detection.” J. Liq. Chromatogr. Related. Technol. 2017, accepted version posted on line August 4, (DOI: 10.1080/10826076.2017.1360907).
45] Cole, K. P.; Groh, J. M.; Johnson, M. D.; Burcham, C. L.; Campbell, B. M.; Diseroad, W. D.; Heller, M. R.; Howell, J. R.; Kallman, N. J.; Koenig, T. M.; May, S. A; Miller, R. D.; Mitchell, D.; Myers, D. P.; Myers, S. S.; Phillips, J. P.; Polster, C. S.; White, T. D.; Cashman, J.; Hurley, D.; Moylan, R.; Sheehan, P.; Spencer, R. D.; Desmond, K.; Desmond, P.; Gowran, O. “Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow
CGMP conditions.” Science, 2017, 356(6343), 1144-1150.
44] Sharif, S.; Day, J.; Hunter, H. N.; Lu, Y.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “Cross-coupling of primary amides to aryl- and heteroaryl-partners using (DiMeIHeptCl)Pd promoted by trialkylboranes or BCF.” J. Am. Chem. Soc. 2017, ASAP (Web 16 Oct 2017).
43] Khadra, A.; Mayer, S.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “A General Protocol for the Broad-Spectrum Cross-Coupling of Nonactivated Sterically Hindered 1° and 2° Amines.” Organometallics 2017, 36(17), 3365-3370.
42] Lombardi, C.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. “Pd-PEPPSI-IPentCl-Catalyzed Amination Using Aminotriphenylsilane as an Ammonia Surrogate.” European Journal of Organic Chemistry, 2017, 11, 1510-1513.
41] Lombardi, C.; Day, J.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Farmer, J. L.; Organ, M. G. “Selective Cross-Coupling of (Hetero)aryl Halides with Ammonia To Produce Primary Arylamines using Pd-NHC Complexes.” Organometallics, 2017, 36(2), 251-254.
40] Organ, M. G.; Sharif, S.; Mitchell, D.; Rodriguez, M.; Farmer, J. L. A. “N-Heteroarylation of Optically Pure α-Amino Esters using the Pd-PEPPSI-IPentCl-o-picoline Pre-catalyst.” Chemistry – A European Journal 2016, 22(42), 14860-14863.
39] Organ, M. G.; Atwater, B.; Rodriguez, M. J.; Chandrasoma, N.; Mitchell, D. “Pd-PEPPSI-IHeptCl: A General Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs.” Chemistry – A European Journal, 2016, 22(41), 14531-14534.
38] Kallman, N. J.; Cole, K. P.; Koenig, T. M.; Buser, J. Y.; McFarland, A. D.; McNulty, L. M.; Mitchell, D. “Synthesis of Aminopyrazoles from Isoxazoles: Comparison of Preparative
Methods by in situ NMR Analysis.” Synthesis, 2016, 48, 3537-3543.
37] Cole, K. P.; Campbell, B. M.; Forst, M. B.; McClary G. J.; Hess, M.; Johnson, M. D.; Miller, R. D.; Mitchell, D.; Polster, C. S.; Reizman, B. “An Automated Intermittent Flow Approach to Continuous Suzuki Coupling.” Org. Process Res. Dev. 2016, 20(4), 820-830.
36] Sharif, S.; Rucker, R. P.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Froese, R. D. J.; Organ, M. G. “Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst.” Angew. Chem. Int. Ed. 2015, 54 (33), 9507-9511.
35] Atwater, B.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Pompeo, M.; Froese, R. D. J.; Organ, M. G. “The Selective Cross-Coupling of Secondary Alkyl Zinc Reagents to Five-Membered-Ring Heterocycles Using Pd-PEPPSI-IHept(Cl).” Angew. Chem. Int. Ed. 2015, 54 (33), 9502-9506.
34] Deasy, R. E.; Slattery, C. N.; Kissane, M.; McNamara, O. A.; Lynch, D.; Maguire, A. R.; Moynihan, H. A.; O’Keeffe, S.; Kopach, M. E.; Mitchell, D.; Magnus, N. A.; Kjell, D. P.; Moher, E. D. “Leveraging an Industrial-Academic Partnership To Optimize Small Molecule Process Development within the Pharmaceutical Industry.” Org. Process Res. Dev. 2015, 19 (2), 344-346.
33] Mitchell, D.; Luo, Y.; McNulty, L. M.; Buser, J. Y.; McFarland, A. D. “A Convenient and Practical Synthesis of Aminopyrazole.” Synthesis, 2015, 47, 235-241.
32] Ritter, S. K. interview with D. Mitchell. “Living Up to the Process Challenge.” Chem. Eng. News. 2014, 93(12), 30-33.
31] Grainger, D. M.; Zanotti-Gerosa, A.; Cole, K. P.; Mitchell, D.; May, S. A.; Pollock, P. M.; Calvin, J. R. “Development of a Stepwise Reductive Deoxygenation Process by Ru-Catalyzed Homogeneous Ketone Reduction and Pd-Catalysed Hydrogenolysis in the Presence of Cu Salts.” ChemCatChem. 2013, 5, 1205-1210.
30] Campbell, A. N.; Cole, K. P.; Martinelli, J. R.; May, S. A.; Mitchell, D.; Pollock, P. M.; Sullivan, K. A. “Development of an Alternate Synthesis for a Key JAK2 Inhibitor Intermediate via Sequential C-H Bond Functionalization.” Org. Process Res. Dev. 2013, 17(2), 273-281.
29] Kissane, M.; McNamara, O. A.; Mitchell, D.; Coppert, D. M.; Humphrey, M. A.; Lorentz, K. T.; Maguire, A. R. “Expanded scope of heterocyclic biaryl synthesis via a palladium-catalysed thermal decarboxylative cross-coupling reaction.” Tetrahedron Lett. 2012, 53 (4), 403-405.
28] Mitchell, D.; Cole, K. P.; Pollock, P. M.; Coppert, D. M.; Burkholder; T. P.; Clayton, J. R. “Development and a practical Synthesis of the JAK2 Inhibitor LY2784544.” Org. Process Res. Dev. 2012, 16 (1), 70-81.
27] Mitchell, D.; Coppert, D.; Moynihan, H. A.; Lorenz, K. T; Kissane, M.; McNamera, O. A.; Maguire, A. R. “A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature.” Org. Process Res. Dev. 2011, 15, 981-985.
26] Halford, B. (with Mitchell, D.) “From a Teaspoon to a Ton,” Chem. Eng. News. 2010, 88(36), 17-28.
25] Cole, K. P.; Mitchell, D. Carr, M. A.; Stout, J. R; Belvo, M. D. “Synthesis and axial chirality of an enantiopure aminodibenzazepinone.” Tetrahedron: Asymmetry, 2009, 20(11), 1262-1266.
24] Boini, S. K.; Vaid R. K.; Mitchell, D.; Moder, K. P. “Synthesis of a substituted benzazepin-2-one dehydrate.” Synthesis, 2009, 12, 1983-1986.
23] Yates, M. H.; Koenig, T. M.; Kallman, N. J.; Ley, C. P.; Mitchell, D. “An Efficient Synthesis of a Multipotent Eicosanoid Pathway Modulator.” Org. Process Res. Dev. 2009, 13(2), 268-275.
22] Pu, Y. J.; Vaid, R. K.; Boini, S. K.; Towsley, R. W.; Doecke, C. W.; Mitchell, D. “A practical method for functionalized peptide or amide bond formation in aqueous-ethanol media with EDC as activator.” Org. Process Res. Dev. 2009, 13(2), 310-314.
21] Xie, C.; Sullivan, K.; Pu, J.; Mitchell, D. “Selective Monoarylation of Benzenediols via Dianion Intermediates.” Syn. Comm. 2008, 38, 21-32.
20] Zhang, F.; Mitchell, D.; Pollock, P.; Zhang, T. “Efficient synthesis of 3-oxygenated benzothiophene derivatives.” Tetrahedron Lett. 2007, 48, 2349-2352.
19] Yu, Y.; Stephenson, G. A.; Mitchell, D. “Benzoazepinone Synthesis: Seven Membered Ring Formation by Palladium-Catalyzed Cyclization of Alkynyl Benzeneacetamides.” Tetrahedron. Lett. 2006, 47, 3811-3814.
18] Wan, Z.; Jones, C. D.; Mitchell, D.; Pu, J. Y.; Zhang, T. Y. “Practical Method for Transforming Alkynes into -Diketones.” J. Org. Chem. 2006, 71(2), 826-828.
17] Mitchell, D.; Audia, J. A.; Buccilli, L. A.; Koenig, T. M.; McDaniel, S, L.; Nissen, J. S. “Dynamic and Chemical Resolution of Aminobenzoazepinone.” Tetrahedron: Asymmetry, 2005, 16, 3814-3819.
16] Mitchell, D.; Yu, H. “Synthetic Application of Palladium-Catalyzed Hydroarylation and Related Systems” Current Opinion in Drug Discovery and Development, 2003, 6(6), 876-883.
15] Wan, Z.; Jones, D. C; Koenig, T. M.; Pu, Y. J.; Mitchell, D.; “Vinyl Aryl Ethers from Copper-Catalyzed Coupling of Vinyl Halides and Phenols.” Tetrahedron Lett. 2003, 44, 8257-8259.
14] Godfrey, A. G.; Brooks, D. A.; McCarthy, J.; Hay, L. A.; Wepsiec, J.; Peters, M.; Mitchell, D. “Application of the Dakin-West Reaction for the Synthesis of Oxazole-Containing Dual PPAR a/g agonist.” J. Org. Chem. 2003, 68, 2623-2632.
13] Robbins, D. K.; Dodson, P. N.; Buccilli, L. A.; Mitchell, D. “Utilizing Capillary Gas Chromatography Mass Spectrometry to Determine 4-Benzotrifluoride t-Butyl Ether as a Reaction By-Product in Fluoxetine Synthesized using Potassium t-Butoxide as Base.” J. Pharm. Biomed. Anal. 2003, 31(1), 63-74.
12] Mitchell, D. “ From Bench Top Research to Pilot-Plant Production and Process Research in the Pharmaceutical Industry.” (ACS Volume, Book Chapter). September 15, 2000.
11] Hay, L. A.; Koenig, T. M.; Ginah, F. O.; Copp, J. D.; Mitchell, D. “Palladium-Catalyzed Hydroarylation of Propiolamides. A Regio- and Stereocontrolled Method for Preparing 3,3-Diaryl Acrylamides.” J. Org. Chem. 1998, 63, 15, 5050-5058.
10] Hay, L. A.; Mitchell, D. “A Regio- and Stereocontrolled Method for Preparing 3,3-Diaryl Acrylamides.” Tetrahedron Lett. 1997, 38, 6533-6536.
9] Huff, B. E.; Koenig, T. M.; Mitchell, D.; Staszak, M. A. “Synthesis of Unsymmetrical Biaryls Using a Modified Suzuki Cross-Coupling: 4-Biphenylcarbox-aldehyde ([1,1’-Biphenyl]-4-Carboxaldehyde).” Organic Syntheses, 1997, 75, 53-60.
8] Mitchell, D.; Doecke, C. W.; Hay, L. A.; Koenig, T. M.; Wirth, D. D. “Ortho-Hydroxyl Assisted Deoxygenation of Phenones. Regiochemical Control in the Synthesis of Monoprotected Resorcinol and Related Systems.” Tetrahedron Lett. 1995, 36(30), 5335-5338.
7] Mitchell, D.; Koenig, T. M. “Synthesis of R- and S- Fluoxetine, Norfluoxetine and Related Compounds from Styrene Oxide.” Synthetic Commun. 1995, 25(8), 1231-1238.
6] T. M. Koenig and D. Mitchell, “A Convenient Method for Preparing Enantiomerically Pure Norfluoxetine, Fluoxetine and Tomoxetine.” Tetrahedron Lett. 1994, 35(9), 1339-1342.
5] Mitchell, D.; Koenig, T. M. “Regiospecific Opening of 1,2 Epoxides with Acetone Cyanohydrin under Mildly Basic Conditions.” Tetrahedron Lett. 1992, 33(23), 3281-3284.
4] Mitchell, D.; Liebeskind, L. S. “Benzoabikoviromycin, a Potential Antiviral Agent Synthesized by the Palladium-Catalyzed Ring Expansion of 2-Alkynyl-2-hydroxybenzocyclobutenones.” J. Am. Chem. Soc. 1990, 112(1), 291-296.
3] Mitchell, D. “Transition Metal Organometallics in the Synthesis of Biologically Active Molecules: Alkylidene Indianones and Quinines.” Ph.D. Thesis, Emory University, Atlanta, GA, Advisor: Lanny S. Liebeskind, 1989.
2] Liebeskind, L. S.; Chidambaram, R.; Mitchell, D.; Foster, B. “Metal Mediated Route to 5-Membered Rings.” Pure and Applied Chemistry 1988, 60(1), 27-34.
1] Liebeskind, L. S.; Mitchell, D.; Foster, B. “A Stereoselective Palladium
Catalyzed Route to 4-Oxygenated 5-Alkylidene Cyclopentadienes and 3-Oxygenated-2-Alkylidene Indenones.” J. Am. Chem. Soc. 1987, 109(25), 7908-7910.

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